This is an application for Core Support of the MCV-VCU Cancer Center for three years. This support will enable the present Cancer Center to continue to develop as a specialized Cancer Center by supporting the various core components requested. These core components include Administration, Evaluation, Developmental Support, Clinical Immunobiology Unit, Tumor Virology Laboratory (in the second of three years), Tumor Tissue Procurement and Storage Unit, Instrument Service and Maintenance, Tumor Registry and Clinical Data Retrieval Unit, Clinical Cancer Research Unit (CCRU) and a Pharmacokinetics Laboratory. The CCRU will consist of two grant supported beds in the first, three in the second and four in the third grant year period. The MCV-VCU Cancer Center is organized into nine Program Areas which will be supported by the above "core" components. These Program Areas involve basic and clinical research, oncology education, patient care services and a community interaction program.